[Spoiler (click to open)]The "personal issue" Beiste is struggling with in episode 3 (which appears to be touched upon as well in episode 7 with the inclusion of a transgender choir, the return of Unique, and Dot having tweeted she has been on set) is a transition from female to male.
You are literally not going to be surprised by any of this (mods, there are no tags for the S6 eps yet).
[Spoiler (click to open)]The title of the Glee Season 6 premiere is “Loser Like Me”, written by Ryan Murphy, Brad Falchuk and Ian Brennan. Brad Buecker directs
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Entering its sixth and final 13-episode season, GLEE is a musical comedy about a group of ambitious and talented young adults in search of strength, acceptance and, ultimately, their voice
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